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Both support cellular energy metabolism but through different mechanisms

Conversely, a ratio of between 1 and 10 is regarded as a sign that cells are under intense attack

Stem Cells 34 , 28402851 (2016)

In the UK, hydroxocobalamin 1 mg intramuscular injection is used: Without neurological involvement : 1 mg three times weekly for two weeks, then maintenance of 1 mg every two to three months With neurological involvement : 1 mg on alternate days until no further improvement in symptoms, then maintenance of 1 mg every two months Lifelong maintenance is required for pernicious anaemia or other irreversible causes of deficiency Oral B12 supplementation may be appropriate for diet-related deficiency in patients without neurological symptoms and with adequate absorption capacity

using both at the same 1,000ppm concentration creates a complementary dual-action approach that neither ingredient achieves alone